Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver
- Authors: Terent’ev A.A.1, Syatkin S.P.2, Kirichuk A.A.2, Soldatenkov A.T.2, Kutyakov S.V.2, Neborak E.V.2, Shevkun N.A.2, Kuznetsova O.M.2, Skorik A.S.2
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Affiliations:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- Issue: Vol 162, No 6 (2017)
- Pages: 801-807
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238585
- DOI: https://doi.org/10.1007/s10517-017-3717-y
- ID: 238585
Cite item
Abstract
We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.
About the authors
A. A. Terent’ev
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: syata@mail.ru
Russian Federation, Moscow
S. P. Syatkin
Peoples’ Friendship University of Russia
Author for correspondence.
Email: syata@mail.ru
Russian Federation, Moscow
A. A. Kirichuk
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow
A. T. Soldatenkov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow
S. V. Kutyakov
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow
E. V. Neborak
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow
N. A. Shevkun
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow
O. M. Kuznetsova
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow
A. S. Skorik
Peoples’ Friendship University of Russia
Email: syata@mail.ru
Russian Federation, Moscow