Мақаланы E-mail арқылы жіберу Analysis of Gut Microbiota in Patients with Parkinson’s Disease
- Авторлар: Petrov V.1, Saltykova I.1, Zhukova I.1, Alifirova V.1, Zhukova N.1, Dorofeeva Y.1, Tyakht A.2, Kovarsky B.2, Alekseev D.2, Kostryukova E.2, Mironova Y.1, Izhboldina O.1, Nikitina M.1, Perevozchikova T.1, Fait E.1, Babenko V.2, Vakhitova M.2, Govorun V.2,3, Sazonov A.1,4
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Мекемелер:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
- M. V. Lomonosov Moscow State University
- Шығарылым: Том 162, № 6 (2017)
- Беттер: 734-737
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238509
- DOI: https://doi.org/10.1007/s10517-017-3700-7
- ID: 238509
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.
Авторлар туралы
V. Petrov
Siberian State Medical University, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
I. Saltykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
I. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
V. Alifirova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
N. Zhukova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
Yu. Dorofeeva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
A. Tyakht
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow
B. Kovarsky
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow
D. Alekseev
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow
E. Kostryukova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow
Yu. Mironova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
O. Izhboldina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
M. Nikitina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
T. Perevozchikova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
E. Fait
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk
V. Babenko
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow
M. Vakhitova
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow
V. Govorun
Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
Email: vyacheslav.a.petrov@mail.ru
Ресей, Moscow; Moscow
A. Sazonov
Siberian State Medical University, Ministry of Health of the Russian Federation; M. V. Lomonosov Moscow State University
Email: vyacheslav.a.petrov@mail.ru
Ресей, Tomsk; Moscow
