Population Polymorphism of IFNL3 and IFNL4 Genes of Type 3 Interferon Associated with Spontaneous Clearance of Hepatitis C Virus in Representatives of Caucasian and Mongoloid Races
- Авторы: Malov I.1, Malov S.1, Savilov E.2,3, Gantulga D.4, Stepanenko L.1, Ogarkov O.2,3, Nyamkhuu D.4, Aitov K.1, Nyamdawa P.4, Kolesnikov S.2
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Учреждения:
- Irkutsk State Medical University
- Research Center of Problems of Family Health and Human Reproduction
- Irkutsk State Medical Academy of Post-Graduate Education
- National Center of Investigation of Infectious Diseases
- Выпуск: Том 161, № 3 (2016)
- Страницы: 404-407
- Раздел: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/237463
- DOI: https://doi.org/10.1007/s10517-016-3425-z
- ID: 237463
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Аннотация
The frequency of single nucleotide polymorphisms of IFNL3 gene (rsl12979860 and rs8099917) and dinucleotide polymorphism of IFNL4 gene (ss469415590) were estimated in healthy inhabitants of Mongolia and Irkutsk regions taking into account their races. Population and genetic studies were performed in 1520 conventionally healthy volunteers (blood donors), representatives of Caucasian and Mongoloid races. Significant race-related differences in the incidence of IFNL3 and IFNL4 gene polymorphisms associated with spontaneous clearance of hepatitis C virus were found in healthy volunteers.
Об авторах
I. Malov
Irkutsk State Medical University
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk
S. Malov
Irkutsk State Medical University
Автор, ответственный за переписку.
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk
E. Savilov
Research Center of Problems of Family Health and Human Reproduction; Irkutsk State Medical Academy of Post-Graduate Education
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk; Irkutsk
D. Gantulga
National Center of Investigation of Infectious Diseases
Email: sikolesnikov2012@gmail.com
Монголия, Ulan-Bator
L. Stepanenko
Irkutsk State Medical University
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk
O. Ogarkov
Research Center of Problems of Family Health and Human Reproduction; Irkutsk State Medical Academy of Post-Graduate Education
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk; Irkutsk
D. Nyamkhuu
National Center of Investigation of Infectious Diseases
Email: sikolesnikov2012@gmail.com
Монголия, Ulan-Bator
K. Aitov
Irkutsk State Medical University
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk
P. Nyamdawa
National Center of Investigation of Infectious Diseases
Email: sikolesnikov2012@gmail.com
Монголия, Ulan-Bator
S. Kolesnikov
Research Center of Problems of Family Health and Human Reproduction
Email: sikolesnikov2012@gmail.com
Россия, Irkutsk