Population Polymorphism of IFNL3 and IFNL4 Genes of Type 3 Interferon Associated with Spontaneous Clearance of Hepatitis C Virus in Representatives of Caucasian and Mongoloid Races
- Authors: Malov I.V.1, Malov S.I.1, Savilov E.D.2,3, Gantulga D.4, Stepanenko L.A.1, Ogarkov O.B.2,3, Nyamkhuu D.4, Aitov K.A.1, Nyamdawa P.4, Kolesnikov S.I.2
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Affiliations:
- Irkutsk State Medical University
- Research Center of Problems of Family Health and Human Reproduction
- Irkutsk State Medical Academy of Post-Graduate Education
- National Center of Investigation of Infectious Diseases
- Issue: Vol 161, No 3 (2016)
- Pages: 404-407
- Section: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/237463
- DOI: https://doi.org/10.1007/s10517-016-3425-z
- ID: 237463
Cite item
Abstract
The frequency of single nucleotide polymorphisms of IFNL3 gene (rsl12979860 and rs8099917) and dinucleotide polymorphism of IFNL4 gene (ss469415590) were estimated in healthy inhabitants of Mongolia and Irkutsk regions taking into account their races. Population and genetic studies were performed in 1520 conventionally healthy volunteers (blood donors), representatives of Caucasian and Mongoloid races. Significant race-related differences in the incidence of IFNL3 and IFNL4 gene polymorphisms associated with spontaneous clearance of hepatitis C virus were found in healthy volunteers.
About the authors
I. V. Malov
Irkutsk State Medical University
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk
S. I. Malov
Irkutsk State Medical University
Author for correspondence.
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk
E. D. Savilov
Research Center of Problems of Family Health and Human Reproduction; Irkutsk State Medical Academy of Post-Graduate Education
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk; Irkutsk
D. Gantulga
National Center of Investigation of Infectious Diseases
Email: sikolesnikov2012@gmail.com
Mongolia, Ulan-Bator
L. A. Stepanenko
Irkutsk State Medical University
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk
O. B. Ogarkov
Research Center of Problems of Family Health and Human Reproduction; Irkutsk State Medical Academy of Post-Graduate Education
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk; Irkutsk
D. Nyamkhuu
National Center of Investigation of Infectious Diseases
Email: sikolesnikov2012@gmail.com
Mongolia, Ulan-Bator
K. A. Aitov
Irkutsk State Medical University
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk
P. Nyamdawa
National Center of Investigation of Infectious Diseases
Email: sikolesnikov2012@gmail.com
Mongolia, Ulan-Bator
S. I. Kolesnikov
Research Center of Problems of Family Health and Human Reproduction
Email: sikolesnikov2012@gmail.com
Russian Federation, Irkutsk