Отправить статью по E-mail In Vitro Study of Cytophysiological Characteristics of Multinuclear Macrophages from Intact and BCG-Infected Mice
- Авторы: Il’in D.1, Arkhipov S.1,2, Shkurupy V.1
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Учреждения:
- Research Institute of Experimental and Clinical Medicine, Siberian Division of the Russian Academy of Medical Sciences
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 160, № 5 (2016)
- Страницы: 668-671
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236876
- DOI: https://doi.org/10.1007/s10517-016-3245-1
- ID: 236876
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Аннотация
Peritoneal macrophages were isolated from intact and BCG-infected BALB/c mice and explanted in vitro. Multinuclear macrophages formed in these cultures differed by the number of nuclei, expression of apoptosis inductors and regulators (TNF-α, p53 protein, caspase 3, and Bcl-2 protein), and cytophysiological characteristics (phagocytic activity, ROS generation, and antimycobacterial properties). Our results indicate that the formation of multinuclear macrophages is accompanied by induction of apoptosis (p53 signaling pathway) and appearance of multinuclear macrophage-derived cells characterized by high phagocytic and antimycobacterial activity.
Об авторах
D. Il’in
Research Institute of Experimental and Clinical Medicine, Siberian Division of the Russian Academy of Medical Sciences
Email: arkhipov@centercem.ru
Россия, Tomsk
S. Arkhipov
Research Institute of Experimental and Clinical Medicine, Siberian Division of the Russian Academy of Medical Sciences; Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: arkhipov@centercem.ru
Россия, Tomsk; Novosibirsk
V. Shkurupy
Research Institute of Experimental and Clinical Medicine, Siberian Division of the Russian Academy of Medical Sciences
Email: arkhipov@centercem.ru
Россия, Tomsk
