Enviar artigo por via de e-mail Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors
- Autores: Mitroshina E.1, Mishchenko T.1, Shishkina T.1, Vedunova M.1
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Afiliações:
- N. I. Lobachevsky Nizhny Novgorod National Research State University
- Edição: Volume 167, Nº 4 (2019)
- Páginas: 574-579
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241909
- DOI: https://doi.org/10.1007/s10517-019-04574-1
- ID: 241909
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Resumo
We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.
Sobre autores
E. Mitroshina
N. I. Lobachevsky Nizhny Novgorod National Research State University
Autor responsável pela correspondência
Email: helenmitroshina@gmail.com
Rússia, Nizhny Novgorod
T. Mishchenko
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: helenmitroshina@gmail.com
Rússia, Nizhny Novgorod
T. Shishkina
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: helenmitroshina@gmail.com
Rússia, Nizhny Novgorod
M. Vedunova
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: helenmitroshina@gmail.com
Rússia, Nizhny Novgorod
