Email this article Role of Neurotrophic Factors BDNF and GDNF in Nervous System Adaptation to the Influence of Ischemic Factors
- Authors: Mitroshina E.V.1, Mishchenko T.A1, Shishkina T.V.1, Vedunova M.V.1
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Affiliations:
- N. I. Lobachevsky Nizhny Novgorod National Research State University
- Issue: Vol 167, No 4 (2019)
- Pages: 574-579
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241909
- DOI: https://doi.org/10.1007/s10517-019-04574-1
- ID: 241909
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Abstract
We developed a complex in vitro model of ischemic damage. Analysis of hippocampal cell viability in primary cultures after modeling of various stress factors revealed the features of action of the main pathological factors of ischemia. Neurotrophic factors BDNF and GDNF produced pronounced neuroprotective effect during modeling both the complex ischemic damage and its individual pathophysiological components. Neurotrophic factor GDNF produced the most pronounced protective effect.
About the authors
E. V. Mitroshina
N. I. Lobachevsky Nizhny Novgorod National Research State University
Author for correspondence.
Email: helenmitroshina@gmail.com
Russian Federation, Nizhny Novgorod
T. A Mishchenko
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: helenmitroshina@gmail.com
Russian Federation, Nizhny Novgorod
T. V. Shishkina
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: helenmitroshina@gmail.com
Russian Federation, Nizhny Novgorod
M. V. Vedunova
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: helenmitroshina@gmail.com
Russian Federation, Nizhny Novgorod
