Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons

I. S. Povarov; R. V. Kondratenko; V. I. Derevyagin; N. F. Myasoedov; V. G. Skrebitsky

doi:10.1007/s10517-017-3676-3

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons

Autores: Povarov I.¹, Kondratenko R.¹, Derevyagin V.¹, Myasoedov N.², Skrebitsky V.¹
Afiliações:
1. Research Center of Neurology
2. Institute of Molecular Genetics, Russian Academy of Sciences
Edição: Volume 162, Nº 5 (2017)
Páginas: 640-642
Seção: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238425
DOI: https://doi.org/10.1007/s10517-017-3676-3
ID: 238425

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Resumo

Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.