Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons
- Authors: Povarov I.S.1, Kondratenko R.V.1, Derevyagin V.I.1, Myasoedov N.F.2, Skrebitsky V.G.1
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Affiliations:
- Research Center of Neurology
- Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 162, No 5 (2017)
- Pages: 640-642
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238425
- DOI: https://doi.org/10.1007/s10517-017-3676-3
- ID: 238425
Cite item
Abstract
Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.
About the authors
I. S. Povarov
Research Center of Neurology
Author for correspondence.
Email: povarovigor@mail.ru
Russian Federation, Moscow
R. V. Kondratenko
Research Center of Neurology
Email: povarovigor@mail.ru
Russian Federation, Moscow
V. I. Derevyagin
Research Center of Neurology
Email: povarovigor@mail.ru
Russian Federation, Moscow
N. F. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: povarovigor@mail.ru
Russian Federation, Moscow
V. G. Skrebitsky
Research Center of Neurology
Email: povarovigor@mail.ru
Russian Federation, Moscow