Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons

I. S. Povarov; R. V. Kondratenko; V. I. Derevyagin; N. F. Myasoedov; V. G. Skrebitsky

doi:10.1007/s10517-017-3676-3

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons

Authors: Povarov I.S.¹, Kondratenko R.V.¹, Derevyagin V.I.¹, Myasoedov N.F.², Skrebitsky V.G.¹
Affiliations:
1. Research Center of Neurology
2. Institute of Molecular Genetics, Russian Academy of Sciences
Issue: Vol 162, No 5 (2017)
Pages: 640-642
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238425
DOI: https://doi.org/10.1007/s10517-017-3676-3
ID: 238425

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Abstract

Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.