Enviar artigo por via de e-mail Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development
- Autores: Menshanov P.1, Bannova A.2, Dygalo N.1
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Afiliações:
- Department of Physiology, Novosibirsk State University
- Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Edição: Volume 160, Nº 4 (2016)
- Páginas: 459-461
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236732
- DOI: https://doi.org/10.1007/s10517-016-3196-6
- ID: 236732
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Resumo
Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.
Sobre autores
P. Menshanov
Department of Physiology, Novosibirsk State University
Autor responsável pela correspondência
Email: dxkorell@gmail.com
Rússia, Novosibirsk
A. Bannova
Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dxkorell@gmail.com
Rússia, Novosibirsk
N. Dygalo
Department of Physiology, Novosibirsk State University
Email: dxkorell@gmail.com
Rússia, Novosibirsk
