Email this article Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development
- Authors: Menshanov P.N.1, Bannova A.V.2, Dygalo N.N.1
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Affiliations:
- Department of Physiology, Novosibirsk State University
- Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 160, No 4 (2016)
- Pages: 459-461
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236732
- DOI: https://doi.org/10.1007/s10517-016-3196-6
- ID: 236732
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Abstract
Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.
About the authors
P. N. Menshanov
Department of Physiology, Novosibirsk State University
Author for correspondence.
Email: dxkorell@gmail.com
Russian Federation, Novosibirsk
A. V. Bannova
Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dxkorell@gmail.com
Russian Federation, Novosibirsk
N. N. Dygalo
Department of Physiology, Novosibirsk State University
Email: dxkorell@gmail.com
Russian Federation, Novosibirsk
