Отправить статью по E-mail Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development
- Авторы: Menshanov P.1, Bannova A.2, Dygalo N.1
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Учреждения:
- Department of Physiology, Novosibirsk State University
- Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Выпуск: Том 160, № 4 (2016)
- Страницы: 459-461
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236732
- DOI: https://doi.org/10.1007/s10517-016-3196-6
- ID: 236732
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Аннотация
Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.
Об авторах
P. Menshanov
Department of Physiology, Novosibirsk State University
Автор, ответственный за переписку.
Email: dxkorell@gmail.com
Россия, Novosibirsk
A. Bannova
Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dxkorell@gmail.com
Россия, Novosibirsk
N. Dygalo
Department of Physiology, Novosibirsk State University
Email: dxkorell@gmail.com
Россия, Novosibirsk
