Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages
- Авторлар: Teselkin Y.1, Khoreva M.1, Veselova A.1, Babenkova I.1, Osipov A.1, Gankovskaya L.1, Vladimirov Y.1
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Мекемелер:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 166, № 1 (2018)
- Беттер: 26-30
- Бөлім: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/240806
- DOI: https://doi.org/10.1007/s10517-018-4281-9
- ID: 240806
Дәйексөз келтіру
Аннотация
TLR2-mediated ROS production by mouse peritoneal macrophages was studied by luminoldependent chemiluminescence under conditions of cell stimulation with zymosan (TLR2/6 ligand) and peptidoglycan (TLR2/1 ligand). ROS production by macrophages stimulated with zymosan and peptidoglycan simultaneously depended on the ratio of ligand concentrations. Three effects were revealed: additivity of the stimulating effects of the ligands used, competitive ligand binding, and effect of macrophage priming with peptidoglycan during cell stimulation with zymosan. The mechanisms of these effects are discussed.
Авторлар туралы
Yu. Teselkin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: teselkin-box@mail.ru
Ресей, Moscow
M. Khoreva
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Ресей, Moscow
A. Veselova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Ресей, Moscow
I. Babenkova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Ресей, Moscow
A. Osipov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Ресей, Moscow
L. Gankovskaya
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Ресей, Moscow
Yu. Vladimirov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Ресей, Moscow
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