Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages
- Авторы: Teselkin Y.1, Khoreva M.1, Veselova A.1, Babenkova I.1, Osipov A.1, Gankovskaya L.1, Vladimirov Y.1
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Учреждения:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 166, № 1 (2018)
- Страницы: 26-30
- Раздел: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/240806
- DOI: https://doi.org/10.1007/s10517-018-4281-9
- ID: 240806
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Аннотация
TLR2-mediated ROS production by mouse peritoneal macrophages was studied by luminoldependent chemiluminescence under conditions of cell stimulation with zymosan (TLR2/6 ligand) and peptidoglycan (TLR2/1 ligand). ROS production by macrophages stimulated with zymosan and peptidoglycan simultaneously depended on the ratio of ligand concentrations. Three effects were revealed: additivity of the stimulating effects of the ligands used, competitive ligand binding, and effect of macrophage priming with peptidoglycan during cell stimulation with zymosan. The mechanisms of these effects are discussed.
Об авторах
Yu. Teselkin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: teselkin-box@mail.ru
Россия, Moscow
M. Khoreva
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Россия, Moscow
A. Veselova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Россия, Moscow
I. Babenkova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Россия, Moscow
A. Osipov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Россия, Moscow
L. Gankovskaya
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Россия, Moscow
Yu. Vladimirov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: teselkin-box@mail.ru
Россия, Moscow
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