Directed Change in TNFα Specificity to Create DR5 Antagonists
- Авторлар: Ukrainskaya V.1, Bobik T.1, Argentova-Stevens A.1, Slutskaya E.1, Kalinin R.1, Gabibov A.1, Stepanov A.1
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Мекемелер:
- Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Шығарылым: Том 165, № 3 (2018)
- Беттер: 386-389
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240329
- DOI: https://doi.org/10.1007/s10517-018-4176-9
- ID: 240329
Дәйексөз келтіру
Аннотация
Death receptor 5 (DR5) is a promising target for antitumor therapy due to its high expression on different tumor cells. Resistance of various tumor cells against TRAIL, a natural ligand for the death receptors, reduces its therapeutic potential and prompts the search for novel agonists at these receptors. Previous screening across the combinatorial peptide library yielded a peptide sequence KVVLTHR that specifically binds DR5. Incorporation of this sequence into TNFα resulted in binding DR5 with mutant protein TNFα-mut and appearance of cytotoxicity against lymphoma cells.
Авторлар туралы
V. Ukrainskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
T. Bobik
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
A. Argentova-Stevens
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
E. Slutskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
R. Kalinin
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
A. Gabibov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
A. Stepanov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: stepanov.aleksei@gmail.com
Ресей, Moscow
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