Directed Change in TNFα Specificity to Create DR5 Antagonists
- 作者: Ukrainskaya V.1, Bobik T.1, Argentova-Stevens A.1, Slutskaya E.1, Kalinin R.1, Gabibov A.1, Stepanov A.1
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隶属关系:
- Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- 期: 卷 165, 编号 3 (2018)
- 页面: 386-389
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240329
- DOI: https://doi.org/10.1007/s10517-018-4176-9
- ID: 240329
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详细
Death receptor 5 (DR5) is a promising target for antitumor therapy due to its high expression on different tumor cells. Resistance of various tumor cells against TRAIL, a natural ligand for the death receptors, reduces its therapeutic potential and prompts the search for novel agonists at these receptors. Previous screening across the combinatorial peptide library yielded a peptide sequence KVVLTHR that specifically binds DR5. Incorporation of this sequence into TNFα resulted in binding DR5 with mutant protein TNFα-mut and appearance of cytotoxicity against lymphoma cells.
作者简介
V. Ukrainskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow
T. Bobik
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow
A. Argentova-Stevens
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow
E. Slutskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow
R. Kalinin
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow
A. Gabibov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow
A. Stepanov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: stepanov.aleksei@gmail.com
俄罗斯联邦, Moscow