Directed Change in TNFα Specificity to Create DR5 Antagonists
- Авторы: Ukrainskaya V.1, Bobik T.1, Argentova-Stevens A.1, Slutskaya E.1, Kalinin R.1, Gabibov A.1, Stepanov A.1
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Учреждения:
- Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Выпуск: Том 165, № 3 (2018)
- Страницы: 386-389
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240329
- DOI: https://doi.org/10.1007/s10517-018-4176-9
- ID: 240329
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Аннотация
Death receptor 5 (DR5) is a promising target for antitumor therapy due to its high expression on different tumor cells. Resistance of various tumor cells against TRAIL, a natural ligand for the death receptors, reduces its therapeutic potential and prompts the search for novel agonists at these receptors. Previous screening across the combinatorial peptide library yielded a peptide sequence KVVLTHR that specifically binds DR5. Incorporation of this sequence into TNFα resulted in binding DR5 with mutant protein TNFα-mut and appearance of cytotoxicity against lymphoma cells.
Об авторах
V. Ukrainskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Россия, Moscow
T. Bobik
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Россия, Moscow
A. Argentova-Stevens
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Россия, Moscow
E. Slutskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Россия, Moscow
R. Kalinin
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Россия, Moscow
A. Gabibov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Россия, Moscow
A. Stepanov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: stepanov.aleksei@gmail.com
Россия, Moscow
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