Directed Change in TNFα Specificity to Create DR5 Antagonists
- Authors: Ukrainskaya V.M.1, Bobik T.V.1, Argentova-Stevens A.1, Slutskaya E.A.1, Kalinin R.S.1, Gabibov A.G.1, Stepanov A.V.1
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Affiliations:
- Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 165, No 3 (2018)
- Pages: 386-389
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240329
- DOI: https://doi.org/10.1007/s10517-018-4176-9
- ID: 240329
Cite item
Abstract
Death receptor 5 (DR5) is a promising target for antitumor therapy due to its high expression on different tumor cells. Resistance of various tumor cells against TRAIL, a natural ligand for the death receptors, reduces its therapeutic potential and prompts the search for novel agonists at these receptors. Previous screening across the combinatorial peptide library yielded a peptide sequence KVVLTHR that specifically binds DR5. Incorporation of this sequence into TNFα resulted in binding DR5 with mutant protein TNFα-mut and appearance of cytotoxicity against lymphoma cells.
About the authors
V. M. Ukrainskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow
T. V. Bobik
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow
A. Argentova-Stevens
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow
E. A. Slutskaya
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow
R. S. Kalinin
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow
A. G. Gabibov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow
A. V. Stepanov
Laboratory of Biocatalysis, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: stepanov.aleksei@gmail.com
Russian Federation, Moscow