Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis
- Авторлар: Motin Y.1, Lepilov A.1, Bgatova N.2, Zharikov A.1, Motina N.1, Lapii G.3, Lushnikova E.3, Nepomnyashchikh L.3
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Мекемелер:
- Altai State Medical University
- Research Institute of Clinical and Experimental Lymphology
- Institute of Molecular Pathology and Pathomorphology
- Шығарылым: Том 160, № 3 (2016)
- Беттер: 381-385
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236712
- DOI: https://doi.org/10.1007/s10517-016-3176-x
- ID: 236712
Дәйексөз келтіру
Аннотация
Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.
Авторлар туралы
Yu. Motin
Altai State Medical University
Хат алмасуға жауапты Автор.
Email: pathol@inbox.ru
Ресей, Barnaul
A. Lepilov
Altai State Medical University
Email: pathol@inbox.ru
Ресей, Barnaul
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
A. Zharikov
Altai State Medical University
Email: pathol@inbox.ru
Ресей, Barnaul
N. Motina
Altai State Medical University
Email: pathol@inbox.ru
Ресей, Barnaul
G. Lapii
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
L. Nepomnyashchikh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
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