Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis
- Авторы: Motin Y.1, Lepilov A.1, Bgatova N.2, Zharikov A.1, Motina N.1, Lapii G.3, Lushnikova E.3, Nepomnyashchikh L.3
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Учреждения:
- Altai State Medical University
- Research Institute of Clinical and Experimental Lymphology
- Institute of Molecular Pathology and Pathomorphology
- Выпуск: Том 160, № 3 (2016)
- Страницы: 381-385
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236712
- DOI: https://doi.org/10.1007/s10517-016-3176-x
- ID: 236712
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Аннотация
Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.
Об авторах
Yu. Motin
Altai State Medical University
Автор, ответственный за переписку.
Email: pathol@inbox.ru
Россия, Barnaul
A. Lepilov
Altai State Medical University
Email: pathol@inbox.ru
Россия, Barnaul
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: pathol@inbox.ru
Россия, Novosibirsk
A. Zharikov
Altai State Medical University
Email: pathol@inbox.ru
Россия, Barnaul
N. Motina
Altai State Medical University
Email: pathol@inbox.ru
Россия, Barnaul
G. Lapii
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
L. Nepomnyashchikh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Россия, Novosibirsk
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