Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis
- Authors: Motin Y.G.1, Lepilov A.V.1, Bgatova N.P.2, Zharikov A.Y.1, Motina N.V.1, Lapii G.A.3, Lushnikova E.L.3, Nepomnyashchikh L.M.3
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Affiliations:
- Altai State Medical University
- Research Institute of Clinical and Experimental Lymphology
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 160, No 3 (2016)
- Pages: 381-385
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236712
- DOI: https://doi.org/10.1007/s10517-016-3176-x
- ID: 236712
Cite item
Abstract
Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.
About the authors
Yu. G. Motin
Altai State Medical University
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Barnaul
A. V. Lepilov
Altai State Medical University
Email: pathol@inbox.ru
Russian Federation, Barnaul
N. P. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
A. Yu. Zharikov
Altai State Medical University
Email: pathol@inbox.ru
Russian Federation, Barnaul
N. V. Motina
Altai State Medical University
Email: pathol@inbox.ru
Russian Federation, Barnaul
G. A. Lapii
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
L. M. Nepomnyashchikh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk