Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis
- 作者: Motin Y.1, Lepilov A.1, Bgatova N.2, Zharikov A.1, Motina N.1, Lapii G.3, Lushnikova E.3, Nepomnyashchikh L.3
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隶属关系:
- Altai State Medical University
- Research Institute of Clinical and Experimental Lymphology
- Institute of Molecular Pathology and Pathomorphology
- 期: 卷 160, 编号 3 (2016)
- 页面: 381-385
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236712
- DOI: https://doi.org/10.1007/s10517-016-3176-x
- ID: 236712
如何引用文章
详细
Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.
作者简介
Yu. Motin
Altai State Medical University
编辑信件的主要联系方式.
Email: pathol@inbox.ru
俄罗斯联邦, Barnaul
A. Lepilov
Altai State Medical University
Email: pathol@inbox.ru
俄罗斯联邦, Barnaul
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
A. Zharikov
Altai State Medical University
Email: pathol@inbox.ru
俄罗斯联邦, Barnaul
N. Motina
Altai State Medical University
Email: pathol@inbox.ru
俄罗斯联邦, Barnaul
G. Lapii
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
L. Nepomnyashchikh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
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