Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia
- Authors: Levchenkova O.S.1, Novikov V.E.1, Parfenov E.A.1, Kulagin K.N.1
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Affiliations:
- Department of Pharmacology, Smolensk State Medical University
- Issue: Vol 162, No 2 (2016)
- Pages: 211-214
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238041
- DOI: https://doi.org/10.1007/s10517-016-3578-9
- ID: 238041
Cite item
Abstract
We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.
About the authors
O. S. Levchenkova
Department of Pharmacology, Smolensk State Medical University
Author for correspondence.
Email: os.levchenkova@gmail.com
Russian Federation, Smolensk
V. E. Novikov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Russian Federation, Smolensk
E. A. Parfenov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Russian Federation, Smolensk
K. N. Kulagin
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Russian Federation, Smolensk