Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia
- 作者: Levchenkova O.1, Novikov V.1, Parfenov E.1, Kulagin K.1
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隶属关系:
- Department of Pharmacology, Smolensk State Medical University
- 期: 卷 162, 编号 2 (2016)
- 页面: 211-214
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238041
- DOI: https://doi.org/10.1007/s10517-016-3578-9
- ID: 238041
如何引用文章
详细
We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.
作者简介
O. Levchenkova
Department of Pharmacology, Smolensk State Medical University
编辑信件的主要联系方式.
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk
V. Novikov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk
E. Parfenov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk
K. Kulagin
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
俄罗斯联邦, Smolensk