Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia
- Авторы: Levchenkova O.1, Novikov V.1, Parfenov E.1, Kulagin K.1
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Учреждения:
- Department of Pharmacology, Smolensk State Medical University
- Выпуск: Том 162, № 2 (2016)
- Страницы: 211-214
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238041
- DOI: https://doi.org/10.1007/s10517-016-3578-9
- ID: 238041
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Аннотация
We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.
Об авторах
O. Levchenkova
Department of Pharmacology, Smolensk State Medical University
Автор, ответственный за переписку.
Email: os.levchenkova@gmail.com
Россия, Smolensk
V. Novikov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Россия, Smolensk
E. Parfenov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Россия, Smolensk
K. Kulagin
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Россия, Smolensk