Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia
- Autores: Levchenkova O.1, Novikov V.1, Parfenov E.1, Kulagin K.1
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Afiliações:
- Department of Pharmacology, Smolensk State Medical University
- Edição: Volume 162, Nº 2 (2016)
- Páginas: 211-214
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238041
- DOI: https://doi.org/10.1007/s10517-016-3578-9
- ID: 238041
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Resumo
We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.
Sobre autores
O. Levchenkova
Department of Pharmacology, Smolensk State Medical University
Autor responsável pela correspondência
Email: os.levchenkova@gmail.com
Rússia, Smolensk
V. Novikov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Rússia, Smolensk
E. Parfenov
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Rússia, Smolensk
K. Kulagin
Department of Pharmacology, Smolensk State Medical University
Email: os.levchenkova@gmail.com
Rússia, Smolensk