Email this article Antibacterial Activity of Hybrid Polymeric Scaffold for Reconstruction of Tubular Bone Defects
- Authors: Anisimova N.Y.1,2, Zalepugin D.Y.2, Chernyshova I.V.2, Maksimkin A.V.2, Kiselevskii M.V.1, Senatov F.S.2, Spirina T.S.1, Sitdikova S.M.1, Karaulov A.V.3
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Affiliations:
- Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- Center for Composite Materials, National University of Science and Technology MISIS
- Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 168, No 1 (2019)
- Pages: 58-61
- Section: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/242206
- DOI: https://doi.org/10.1007/s10517-019-04646-2
- ID: 242206
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Abstract
We studied antibacterial activity of a hybrid polymeric construction consisting of continuous and porous layers of ultrahigh-molecular-weight polyethylene reinforced by titanium. Experimental samples were impregnated with amoxycillin in subcritical Freon R22. The contact of bacterial culture with hybrid polymeric constructions saturated with amoxycillin suppressed the growth of microorganisms and the formation of their colonies. These results attest to the presence of a bactericidal effect of hybrid scaffold samples impregnated with an antibacterial component.
About the authors
N. Yu. Anisimova
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; Center for Composite Materials, National University of Science and Technology MISIS
Email: kisele@inbox.ru
Russian Federation, Moscow; Moscow
D. Yu. Zalepugin
Center for Composite Materials, National University of Science and Technology MISIS
Email: kisele@inbox.ru
Russian Federation, Moscow
I. V. Chernyshova
Center for Composite Materials, National University of Science and Technology MISIS
Email: kisele@inbox.ru
Russian Federation, Moscow
A. V. Maksimkin
Center for Composite Materials, National University of Science and Technology MISIS
Email: kisele@inbox.ru
Russian Federation, Moscow
M. V. Kiselevskii
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: kisele@inbox.ru
Russian Federation, Moscow
F. S. Senatov
Center for Composite Materials, National University of Science and Technology MISIS
Email: kisele@inbox.ru
Russian Federation, Moscow
T. S. Spirina
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: kisele@inbox.ru
Russian Federation, Moscow
S. M. Sitdikova
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: kisele@inbox.ru
Russian Federation, Moscow
A. V. Karaulov
Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University (Sechenov University)
Email: kisele@inbox.ru
Russian Federation, Moscow
