Activity of Cathepsin B and Proteome in the Serum and Brain of Rats with Different Behavioral Activity under Conditions of Metabolic Stress

N. V. Kirbaeva; N. E. Sharanova; A. D. Malinkin; A. V. Vasil’ev

doi:10.1007/s10517-018-4250-3

Activity of Cathepsin B and Proteome in the Serum and Brain of Rats with Different Behavioral Activity under Conditions of Metabolic Stress

Authors: Kirbaeva N.V.¹, Sharanova N.E.², Malinkin A.D.¹, Vasil’ev A.V.¹
Affiliations:
1. Federal Research Center of Nutrition and Biotechnology
2. V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Issue: Vol 165, No 6 (2018)
Pages: 721-724
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240707
DOI: https://doi.org/10.1007/s10517-018-4250-3
ID: 240707

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Abstract

Study of the brain and serum of male Wistar rats with the metabolic stress model detected changed proteomic profiles of emotiogenic structures and an increase of cathepsin B activity. Antiapoptotic effect of coenzyme Q10, added to the ration, was detected. Differences in the adaptation response of animals with passive and active behavior under conditions of metabolic stress were detected.