Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals

V. I. Dubrovina; S. V. Balakhonov; O. V. Yurieva; T. P. Starovoitova; N. L. Barannikova; L. E. Tokareva; A. B. Pyatidesyatnikova; K. Yu. Yastremskaya; T. T. Shkaruba

doi:10.1007/s10517-018-4138-2

Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals

Authors: Dubrovina V.I.¹, Balakhonov S.V.¹, Yurieva O.V.¹, Starovoitova T.P.¹, Barannikova N.L.¹, Tokareva L.E.¹, Pyatidesyatnikova A.B.¹, Yastremskaya K.Y.¹, Shkaruba T.T.¹
Affiliations:
1. Irkutsk Antiplague Research Institute of Siberia and Far East
Issue: Vol 165, No 2 (2018)
Pages: 239-242
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240193
DOI: https://doi.org/10.1007/s10517-018-4138-2
ID: 240193

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Abstract

The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant system, due to which the destructive effects of ROS could be partially neutralized during the vaccinal process.