Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals

V. I. Dubrovina; S. V. Balakhonov; O. V. Yurieva; T. P. Starovoitova; N. L. Barannikova; L. E. Tokareva; A. B. Pyatidesyatnikova; K. Yu. Yastremskaya; T. T. Shkaruba

doi:10.1007/s10517-018-4138-2

Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals

作者: Dubrovina V.¹, Balakhonov S.¹, Yurieva O.¹, Starovoitova T.¹, Barannikova N.¹, Tokareva L.¹, Pyatidesyatnikova A.¹, Yastremskaya K.¹, Shkaruba T.¹
隶属关系:
1. Irkutsk Antiplague Research Institute of Siberia and Far East
期: 卷 165, 编号 2 (2018)
页面: 239-242
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240193
DOI: https://doi.org/10.1007/s10517-018-4138-2
ID: 240193

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The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant system, due to which the destructive effects of ROS could be partially neutralized during the vaccinal process.