Email this article Proteomic Study of Blood Serum in Coronary Atherosclerosis
- Authors: Stakhneva E.M.1, Meshcheryakova I.A.2, Demidov E.A.2, Starostin K.V.2, Ragino Y.I.1, Peltek S.E.2, Voevoda M.I.1
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Affiliations:
- Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 162, No 3 (2017)
- Pages: 343-345
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238188
- DOI: https://doi.org/10.1007/s10517-017-3611-7
- ID: 238188
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Abstract
Changes in the blood serum proteins were assessed in men with coronary atherosclerosis and without coronary heart disease. Proteins were separated by 2D-electrophoresis, protein fractions were identified by their peptide fingerprint by MALDI method; fractions with more than twofold increase in protein level were determined. In blood serum of patients with coronary atherosclerosis, the content of C4 complement protein increased and ceruloplasmin level decreased, which is typical of heart failure and coronary heart disease.
About the authors
E. M. Stakhneva
Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
I. A. Meshcheryakova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
E. A. Demidov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
K. V. Starostin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
S. E. Peltek
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
M. I. Voevoda
Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: stakhneva@yandex.ru
Russian Federation, Novosibirsk
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