Email this article Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas
- Authors: Cherepanov S.A.1, Cherepanova K.I.1, Grinenko N.F.2, Antonova O.M.2, Chekhonin V.P.1,2
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Affiliations:
- N. I. Pirogov Russian National Research Medical University
- V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
- Issue: Vol 161, No 5 (2016)
- Pages: 674-678
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237663
- DOI: https://doi.org/10.1007/s10517-016-3483-2
- ID: 237663
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Abstract
We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
About the authors
S. A. Cherepanov
N. I. Pirogov Russian National Research Medical University
Author for correspondence.
Email: cherep-rsmu@yandex.ru
Russian Federation, Moscow
K. I. Cherepanova
N. I. Pirogov Russian National Research Medical University
Email: cherep-rsmu@yandex.ru
Russian Federation, Moscow
N. F. Grinenko
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Russian Federation, Moscow
O. M. Antonova
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Russian Federation, Moscow
V. P. Chekhonin
N. I. Pirogov Russian National Research Medical University; V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Russian Federation, Moscow; Moscow
