Enviar artigo por via de e-mail Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas
- Autores: Cherepanov S.1, Cherepanova K.1, Grinenko N.2, Antonova O.2, Chekhonin V.1,2
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Afiliações:
- N. I. Pirogov Russian National Research Medical University
- V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
- Edição: Volume 161, Nº 5 (2016)
- Páginas: 674-678
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237663
- DOI: https://doi.org/10.1007/s10517-016-3483-2
- ID: 237663
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Resumo
We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
Sobre autores
S. Cherepanov
N. I. Pirogov Russian National Research Medical University
Autor responsável pela correspondência
Email: cherep-rsmu@yandex.ru
Rússia, Moscow
K. Cherepanova
N. I. Pirogov Russian National Research Medical University
Email: cherep-rsmu@yandex.ru
Rússia, Moscow
N. Grinenko
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Rússia, Moscow
O. Antonova
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Rússia, Moscow
V. Chekhonin
N. I. Pirogov Russian National Research Medical University; V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Rússia, Moscow; Moscow
