电邮这篇文章 Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas
- 作者: Cherepanov S.1, Cherepanova K.1, Grinenko N.2, Antonova O.2, Chekhonin V.1,2
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隶属关系:
- N. I. Pirogov Russian National Research Medical University
- V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
- 期: 卷 161, 编号 5 (2016)
- 页面: 674-678
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237663
- DOI: https://doi.org/10.1007/s10517-016-3483-2
- ID: 237663
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详细
We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
作者简介
S. Cherepanov
N. I. Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: cherep-rsmu@yandex.ru
俄罗斯联邦, Moscow
K. Cherepanova
N. I. Pirogov Russian National Research Medical University
Email: cherep-rsmu@yandex.ru
俄罗斯联邦, Moscow
N. Grinenko
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
俄罗斯联邦, Moscow
O. Antonova
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
俄罗斯联邦, Moscow
V. Chekhonin
N. I. Pirogov Russian National Research Medical University; V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
俄罗斯联邦, Moscow; Moscow
