Отправить статью по E-mail Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas
- Авторы: Cherepanov S.1, Cherepanova K.1, Grinenko N.2, Antonova O.2, Chekhonin V.1,2
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Учреждения:
- N. I. Pirogov Russian National Research Medical University
- V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
- Выпуск: Том 161, № 5 (2016)
- Страницы: 674-678
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237663
- DOI: https://doi.org/10.1007/s10517-016-3483-2
- ID: 237663
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Аннотация
We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
Об авторах
S. Cherepanov
N. I. Pirogov Russian National Research Medical University
Автор, ответственный за переписку.
Email: cherep-rsmu@yandex.ru
Россия, Moscow
K. Cherepanova
N. I. Pirogov Russian National Research Medical University
Email: cherep-rsmu@yandex.ru
Россия, Moscow
N. Grinenko
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Россия, Moscow
O. Antonova
V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Россия, Moscow
V. Chekhonin
N. I. Pirogov Russian National Research Medical University; V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology
Email: cherep-rsmu@yandex.ru
Россия, Moscow; Moscow
