Email this article Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia
- Authors: Tregub P.P.1,2, Malinovskaya N.A.3, Kulikov V.P.1,2, Salmina A.B.3, Nagibaeva M.E.1, Zabrodina A.S.1, Gertsog G.E.3, Antonova S.K.3
-
Affiliations:
- Altai State Medical University, Ministry of Health of the Russian Federation
- Reserach Institute of Physiology and Fundamental Medicine
- V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 5 (2016)
- Pages: 666-669
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237655
- DOI: https://doi.org/10.1007/s10517-016-3481-4
- ID: 237655
Cite item
Open Access
Access granted
Subscription Access
Abstract
We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.
About the authors
P. P. Tregub
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Author for correspondence.
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul; Novosibirsk
N. A. Malinovskaya
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Krasnoyarsk
V. P. Kulikov
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul; Novosibirsk
A. B. Salmina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Krasnoyarsk
M. E. Nagibaeva
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul
A. S. Zabrodina
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Barnaul
G. E. Gertsog
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Krasnoyarsk
S. K. Antonova
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Russian Federation, Krasnoyarsk
Supplementary files
