Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia
- 作者: Tregub P.1,2, Malinovskaya N.3, Kulikov V.1,2, Salmina A.3, Nagibaeva M.1, Zabrodina A.1, Gertsog G.3, Antonova S.3
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隶属关系:
- Altai State Medical University, Ministry of Health of the Russian Federation
- Reserach Institute of Physiology and Fundamental Medicine
- V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 161, 编号 5 (2016)
- 页面: 666-669
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237655
- DOI: https://doi.org/10.1007/s10517-016-3481-4
- ID: 237655
如何引用文章
详细
We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.
作者简介
P. Tregub
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
编辑信件的主要联系方式.
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Barnaul; Novosibirsk
N. Malinovskaya
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Krasnoyarsk
V. Kulikov
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Barnaul; Novosibirsk
A. Salmina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Krasnoyarsk
M. Nagibaeva
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Barnaul
A. Zabrodina
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Barnaul
G. Gertsog
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Krasnoyarsk
S. Antonova
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
俄罗斯联邦, Krasnoyarsk