Отправить статью по E-mail Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia
- Авторы: Tregub P.P.1,2, Malinovskaya N.A.3, Kulikov V.P.1,2, Salmina A.B.3, Nagibaeva M.E.1, Zabrodina A.S.1, Gertsog G.E.3, Antonova S.K.3
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Учреждения:
- Altai State Medical University, Ministry of Health of the Russian Federation
- Reserach Institute of Physiology and Fundamental Medicine
- V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 161, № 5 (2016)
- Страницы: 666-669
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237655
- DOI: https://doi.org/10.1007/s10517-016-3481-4
- ID: 237655
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Аннотация
We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.
Об авторах
P. Tregub
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Автор, ответственный за переписку.
Email: pfiza_asmu@mail.ru
Россия, Barnaul; Novosibirsk
N. Malinovskaya
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Krasnoyarsk
V. Kulikov
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Email: pfiza_asmu@mail.ru
Россия, Barnaul; Novosibirsk
A. Salmina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Krasnoyarsk
M. Nagibaeva
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Barnaul
A. Zabrodina
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Barnaul
G. Gertsog
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Krasnoyarsk
S. Antonova
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Россия, Krasnoyarsk
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