Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia
- Autores: Tregub P.1,2, Malinovskaya N.3, Kulikov V.1,2, Salmina A.3, Nagibaeva M.1, Zabrodina A.1, Gertsog G.3, Antonova S.3
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Afiliações:
- Altai State Medical University, Ministry of Health of the Russian Federation
- Reserach Institute of Physiology and Fundamental Medicine
- V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 161, Nº 5 (2016)
- Páginas: 666-669
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237655
- DOI: https://doi.org/10.1007/s10517-016-3481-4
- ID: 237655
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Resumo
We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.
Sobre autores
P. Tregub
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Autor responsável pela correspondência
Email: pfiza_asmu@mail.ru
Rússia, Barnaul; Novosibirsk
N. Malinovskaya
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Rússia, Krasnoyarsk
V. Kulikov
Altai State Medical University, Ministry of Health of the Russian Federation; Reserach Institute of Physiology and Fundamental Medicine
Email: pfiza_asmu@mail.ru
Rússia, Barnaul; Novosibirsk
A. Salmina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Rússia, Krasnoyarsk
M. Nagibaeva
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Rússia, Barnaul
A. Zabrodina
Altai State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Rússia, Barnaul
G. Gertsog
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Rússia, Krasnoyarsk
S. Antonova
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: pfiza_asmu@mail.ru
Rússia, Krasnoyarsk