Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes

E. V. Svirshchevskaya; R. A. Poltavtseva; I. P. Beletskii; I. I. Selezneva; G. T. Sukhikh

doi:10.1007/s10517-016-3451-x

Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes

Authors: Svirshchevskaya E.V.¹, Poltavtseva R.A.², Beletskii I.P.², Selezneva I.I.³, Sukhikh G.T.¹
Affiliations:
1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
2. V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Issue: Vol 161, No 4 (2016)
Pages: 518-522
Section: Microbiology and Immunology
URL: https://journals.rcsi.science/0007-4888/article/view/237559
DOI: https://doi.org/10.1007/s10517-016-3451-x
ID: 237559

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Abstract
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Abstract

We analyzed the interactions between peripheral blood lymphocytes from heterologous donors with mesenchymal stem cells obtained from the tooth pulp and trophoblast. In mixed cultures, proliferation of both lymphocytes and mesenchymal stem cells was suppressed. Similar suppressive effects were observed in lymphocyte cultures mixed with epithelial cells (hepatocytes HeG2 and renal epithelial cells HEK293). This suppression can be determined by impairment of normal adhesion contacts between cells of different origin.

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Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes

Full Text

Abstract

About the authors

E. V. Svirshchevskaya

R. A. Poltavtseva

I. P. Beletskii

I. I. Selezneva

G. T. Sukhikh

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