Antiproliferative Effects of Mesenchymal Stem Cells and Epithelial Cells on Lymphocytes
- Авторы: Svirshchevskaya E.1, Poltavtseva R.2, Beletskii I.2, Selezneva I.3, Sukhikh G.1
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Учреждения:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Выпуск: Том 161, № 4 (2016)
- Страницы: 518-522
- Раздел: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237559
- DOI: https://doi.org/10.1007/s10517-016-3451-x
- ID: 237559
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Аннотация
We analyzed the interactions between peripheral blood lymphocytes from heterologous donors with mesenchymal stem cells obtained from the tooth pulp and trophoblast. In mixed cultures, proliferation of both lymphocytes and mesenchymal stem cells was suppressed. Similar suppressive effects were observed in lymphocyte cultures mixed with epithelial cells (hepatocytes HeG2 and renal epithelial cells HEK293). This suppression can be determined by impairment of normal adhesion contacts between cells of different origin.
Об авторах
E. Svirshchevskaya
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: esvir@mx.ibch.ru
Россия, Moscow
R. Poltavtseva
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Россия, Moscow
I. Beletskii
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Россия, Moscow
I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: esvir@mx.ibch.ru
Россия, Pushchino, Moscow region
G. Sukhikh
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: esvir@mx.ibch.ru
Россия, Moscow