Email this article Bioavailability of the Phenolic Antioxidant 4-Methyl-2,6-Diisobornylphenol After Oral Administration
- Authors: Chernysheva G.A.1, Smolyakova V.I.1, Yanovskaya E.A.2, Kutchin A.V.3, Chukicheva I.Y.3, Udut V.V.2, Plotnikov M.B.1
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Affiliations:
- Laboratory of Pharmacology of Blood Circulation
- Laboratory of Physiology, Molecular and Clinical Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Laboratory of Organic Synthesis and Chemistry of Natural Compounds, Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
- Issue: Vol 161, No 4 (2016)
- Pages: 505-507
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237545
- DOI: https://doi.org/10.1007/s10517-016-3448-5
- ID: 237545
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Abstract
We compared bioavailability of 4-methyl-2,6-diisobornylphenol after single intragastric administration to rats in a dose of 200 mg/kg in starch suspension and in almond oil. Absorption of 4-methyl-2,6-diisobornylphenol in the gastrointestinal tract after administration in almond oil was much more efficient than after administration in aqueous starch mucus.
About the authors
G. A. Chernysheva
Laboratory of Pharmacology of Blood Circulation
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Tomsk
V. I. Smolyakova
Laboratory of Pharmacology of Blood Circulation
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Tomsk
E. A. Yanovskaya
Laboratory of Physiology, Molecular and Clinical Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Author for correspondence.
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Tomsk
A. V. Kutchin
Laboratory of Organic Synthesis and Chemistry of Natural Compounds, Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Syktyvkar, Komi Republic
I. Yu. Chukicheva
Laboratory of Organic Synthesis and Chemistry of Natural Compounds, Institute of Chemistry, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Syktyvkar, Komi Republic
V. V. Udut
Laboratory of Physiology, Molecular and Clinical Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Tomsk
M. B. Plotnikov
Laboratory of Pharmacology of Blood Circulation
Email: elena.yanovskaya@pharmso.ru
Russian Federation, Tomsk
