Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus
- Authors: Gavrilova Y.S.1, Bgatova N.P.1, Klimontov V.V.1, Ischenko I.Y.1, Michurina S.V.1, Myakina N.E.1, Zavyalov E.L.2
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
- Issue: Vol 161, No 4 (2016)
- Pages: 501-504
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237542
- DOI: https://doi.org/10.1007/s10517-016-3447-6
- ID: 237542
Cite item
Abstract
Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
About the authors
Yu. S. Gavrilova
Research Institute of Clinical and Experimental Lymphology
Author for correspondence.
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
N. P. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
V. V. Klimontov
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
I. Yu. Ischenko
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
S. V. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
N. E. Myakina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk
E. L. Zavyalov
Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
Email: inabrite@yandex.ru
Russian Federation, Novosibirsk