Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus
- 作者: Gavrilova Y.1, Bgatova N.1, Klimontov V.1, Ischenko I.1, Michurina S.1, Myakina N.1, Zavyalov E.2
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隶属关系:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
- 期: 卷 161, 编号 4 (2016)
- 页面: 501-504
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237542
- DOI: https://doi.org/10.1007/s10517-016-3447-6
- ID: 237542
如何引用文章
详细
Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
作者简介
Yu. Gavrilova
Research Institute of Clinical and Experimental Lymphology
编辑信件的主要联系方式.
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
V. Klimontov
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
I. Ischenko
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
N. Myakina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
E. Zavyalov
Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
Email: inabrite@yandex.ru
俄罗斯联邦, Novosibirsk
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