Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus
- Авторы: Gavrilova Y.S.1, Bgatova N.P.1, Klimontov V.V.1, Ischenko I.Y.1, Michurina S.V.1, Myakina N.E.1, Zavyalov E.L.2
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Учреждения:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
- Выпуск: Том 161, № 4 (2016)
- Страницы: 501-504
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237542
- DOI: https://doi.org/10.1007/s10517-016-3447-6
- ID: 237542
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Аннотация
Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
Об авторах
Yu. Gavrilova
Research Institute of Clinical and Experimental Lymphology
Автор, ответственный за переписку.
Email: inabrite@yandex.ru
Россия, Novosibirsk
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Россия, Novosibirsk
V. Klimontov
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Россия, Novosibirsk
I. Ischenko
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Россия, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Россия, Novosibirsk
N. Myakina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Россия, Novosibirsk
E. Zavyalov
Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
Email: inabrite@yandex.ru
Россия, Novosibirsk
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