Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus
- Autores: Gavrilova Y.1, Bgatova N.1, Klimontov V.1, Ischenko I.1, Michurina S.1, Myakina N.1, Zavyalov E.2
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Afiliações:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
- Edição: Volume 161, Nº 4 (2016)
- Páginas: 501-504
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237542
- DOI: https://doi.org/10.1007/s10517-016-3447-6
- ID: 237542
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Resumo
Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
Sobre autores
Yu. Gavrilova
Research Institute of Clinical and Experimental Lymphology
Autor responsável pela correspondência
Email: inabrite@yandex.ru
Rússia, Novosibirsk
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Rússia, Novosibirsk
V. Klimontov
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Rússia, Novosibirsk
I. Ischenko
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Rússia, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Rússia, Novosibirsk
N. Myakina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Rússia, Novosibirsk
E. Zavyalov
Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
Email: inabrite@yandex.ru
Rússia, Novosibirsk
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