Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus
- Авторлар: Gavrilova Y.1, Bgatova N.1, Klimontov V.1, Ischenko I.1, Michurina S.1, Myakina N.1, Zavyalov E.2
-
Мекемелер:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
- Шығарылым: Том 161, № 4 (2016)
- Беттер: 501-504
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237542
- DOI: https://doi.org/10.1007/s10517-016-3447-6
- ID: 237542
Дәйексөз келтіру
Аннотация
Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.
Авторлар туралы
Yu. Gavrilova
Research Institute of Clinical and Experimental Lymphology
Хат алмасуға жауапты Автор.
Email: inabrite@yandex.ru
Ресей, Novosibirsk
N. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Ресей, Novosibirsk
V. Klimontov
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Ресей, Novosibirsk
I. Ischenko
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Ресей, Novosibirsk
S. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Ресей, Novosibirsk
N. Myakina
Research Institute of Clinical and Experimental Lymphology
Email: inabrite@yandex.ru
Ресей, Novosibirsk
E. Zavyalov
Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences
Email: inabrite@yandex.ru
Ресей, Novosibirsk
![](/img/style/loading.gif)