Email this article Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity
- Authors: Sakharov D.A.1,2, Rudakovskaya P.G.3, Maltseva D.V.1, Trushkin E.V.1, Tonevitskaya S.A.2
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Affiliations:
- BioClinicum Research and Development Center
- Moscow State University of Mechanical Engineering (MAMI)
- National University of Science and Technology (MISiS)
- Issue: Vol 161, No 1 (2016)
- Pages: 116-119
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/237179
- DOI: https://doi.org/10.1007/s10517-016-3359-5
- ID: 237179
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Abstract
The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo. According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.
About the authors
D. A. Sakharov
BioClinicum Research and Development Center; Moscow State University of Mechanical Engineering (MAMI)
Author for correspondence.
Email: d.sakharov@bioclinicum.com
Russian Federation, Moscow; Moscow
P. G. Rudakovskaya
National University of Science and Technology (MISiS)
Email: d.sakharov@bioclinicum.com
Russian Federation, Moscow
D. V. Maltseva
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
Russian Federation, Moscow
E. V. Trushkin
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
Russian Federation, Moscow
S. A. Tonevitskaya
Moscow State University of Mechanical Engineering (MAMI)
Email: d.sakharov@bioclinicum.com
Russian Federation, Moscow
