Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity
- 作者: Sakharov D.1,2, Rudakovskaya P.3, Maltseva D.1, Trushkin E.1, Tonevitskaya S.2
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隶属关系:
- BioClinicum Research and Development Center
- Moscow State University of Mechanical Engineering (MAMI)
- National University of Science and Technology (MISiS)
- 期: 卷 161, 编号 1 (2016)
- 页面: 116-119
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/237179
- DOI: https://doi.org/10.1007/s10517-016-3359-5
- ID: 237179
如何引用文章
详细
The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo. According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.
作者简介
D. Sakharov
BioClinicum Research and Development Center; Moscow State University of Mechanical Engineering (MAMI)
编辑信件的主要联系方式.
Email: d.sakharov@bioclinicum.com
俄罗斯联邦, Moscow; Moscow
P. Rudakovskaya
National University of Science and Technology (MISiS)
Email: d.sakharov@bioclinicum.com
俄罗斯联邦, Moscow
D. Maltseva
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
俄罗斯联邦, Moscow
E. Trushkin
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
俄罗斯联邦, Moscow
S. Tonevitskaya
Moscow State University of Mechanical Engineering (MAMI)
Email: d.sakharov@bioclinicum.com
俄罗斯联邦, Moscow