Enviar artigo por via de e-mail Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity
- Autores: Sakharov D.1,2, Rudakovskaya P.3, Maltseva D.1, Trushkin E.1, Tonevitskaya S.2
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Afiliações:
- BioClinicum Research and Development Center
- Moscow State University of Mechanical Engineering (MAMI)
- National University of Science and Technology (MISiS)
- Edição: Volume 161, Nº 1 (2016)
- Páginas: 116-119
- Seção: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/237179
- DOI: https://doi.org/10.1007/s10517-016-3359-5
- ID: 237179
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Resumo
The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo. According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.
Sobre autores
D. Sakharov
BioClinicum Research and Development Center; Moscow State University of Mechanical Engineering (MAMI)
Autor responsável pela correspondência
Email: d.sakharov@bioclinicum.com
Rússia, Moscow; Moscow
P. Rudakovskaya
National University of Science and Technology (MISiS)
Email: d.sakharov@bioclinicum.com
Rússia, Moscow
D. Maltseva
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
Rússia, Moscow
E. Trushkin
BioClinicum Research and Development Center
Email: d.sakharov@bioclinicum.com
Rússia, Moscow
S. Tonevitskaya
Moscow State University of Mechanical Engineering (MAMI)
Email: d.sakharov@bioclinicum.com
Rússia, Moscow
